Search Result

Results for "

transcriptional activity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (4) Anaplastic lymphoma kinase (ALK) (1) Androgen Receptor (9) Antibiotic (4) AP-1 (2) Apoptosis (35) Aryl Hydrocarbon Receptor (2) Autophagy (15) Bacterial (8) Bcl-2 Family (4) Beclin1 (2) c-Myc (7) Calcium Channel (2) Calmodulin (1) Cannabinoid Receptor (1) Caspase (1) CDK (5) COX (9) Cryptochrome (1) CXCR (1) Cytochrome P450 (4) Dihydroorotate Dehydrogenase (2) DNA/RNA Synthesis (6) E1/E2/E3 Enzyme (1) Endogenous Metabolite (7) Epigenetic Reader Domain (6) Estrogen Receptor/ERR (8) Fatty Acid Synthase (FASN) (1) Ferroptosis (2) Glucocorticoid Receptor (3) Glucosidase (1) HBV (2) HDAC (1) Hedgehog (1) HIF/HIF Prolyl-Hydroxylase (6) Histone Acetyltransferase (2) Histone Methyltransferase (2) HIV (4) HSP (2) IKK (3) Influenza Virus (4) Isotope-Labeled Compounds (5) JNK (2) Keap1-Nrf2 (2) Ligands for E3 Ligase (1) Ligands for Target Protein for PROTAC (1) LXR (2) MAP4K (1) MDM-2/p53 (9) Microtubule/Tubulin (1) Mineralocorticoid Receptor (1) Mitophagy (4) MMP (5) mTOR (1) MyD88 (1) NF-κB (16) NO Synthase (4) Notch (2) Nucleoside Antimetabolite/Analog (1) Organoid (3) p38 MAPK (1) Parasite (5) PARP (1) PGC-1α (1) Polo-like Kinase (PLK) (1) PPAR (5) Prostaglandin Receptor (1) PROTACs (3) Proteasome (1) RAR/RXR (1) Reactive Oxygen Species (4) REV-ERB (1) Reverse Transcriptase (1) Ribosomal S6 Kinase (RSK) (1) ROR (2) Ser/Thr Protease (1) Sirtuin (4) STAT (9) Survivin (1) TGF-β Receptor (3) TNF Receptor (1) Tyrosinase (1) VEGFR (3) Wnt (6) YAP (6) β-catenin (7)
By Research Areas:	Cancer (126) Cardiovascular Disease (10) Endocrinology (3) Infection (19) Inflammation/Immunology (43) Metabolic Disease (16) Neurological Disease (11)
Click Chemistry:	Azide (1)

192

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-142942

Glucocorticoid receptor-IN-2	Glucocorticoid Receptor MMP	Inflammation/Immunology
Glucocorticoid receptor-IN-2 (Compound WX019) is a selective glucocorticoid receptor (GR) modulator with anti-inflammatory effect. Glucocorticoid receptor-IN-2 exhibits very good transcriptional repressive activity with an IC₅₀ of 0.171 nM against hMMP1, and comparable transcriptional activation activity with an EC₅₀ of 0.94 nM against MMTV .

HY-146184

CCT373567

Bcl-2 Family Cancer

CCT373567 is a potent degrader of transcriptional repressor BCL6, with an IC₅₀ of 2.9 nM. CCT373567 exhibits antiproliferative activity .

CCT373567	Bcl-2 Family	Cancer
CCT373567 is a potent degrader of transcriptional repressor BCL6, with an IC₅₀ of 2.9 nM. CCT373567 exhibits antiproliferative activity .

HY-142941

Glucocorticoid receptor-IN-1	Glucocorticoid Receptor MMP	Inflammation/Immunology
Glucocorticoid receptor-IN-1 (Compound WX002) is a selective glucocorticoid receptor (GR) modulator with anti-inflammatory effect. Glucocorticoid receptor-IN-1 exhibits very good transcriptional repressive activity with an IC₅₀ of 2.11 nM against hMMP1, and transcriptional activation activity with an EC₅₀ of 5.59 nM against MMTV .

HY-118414

20-Ethyl prostaglandin E2	Prostaglandin Receptor	Neurological Disease Cancer
20-Ethyl prostaglandin E2 (compound 62) is a PG analog that stimulates Nurr1-dependent transcriptional activity .

HY-N12011

11-Oxoisomogroside V	PGC-1α	Others
11-Oxoisomogroside V (compound 3) is a cucurbitacin isolated from the crude extract of Luo Han Guo. 11-Oxoisomogroside V activates the transcriptional activity of PGC-1α. In the luciferase experiment, the results showed that 10 μM and 20 μM 11-Oxoisomogroside V could increase the luciferase activity to 133.79% and 143.81% .

HY-143587

CDK7-IN-2	CDK	Cancer
CDK7-IN-2 is a potent inhibitor of CDK7. CDK7 is implicated in both temporal control of the cell cycle and transcriptional activity. CDK7 is implicated in the transcriptional initiation process by phosphorylation of Rbpl subunit of RNA Polymerase II (RNAPII). CDK7 has the potential for the research of cancer disease, in particular aggressive and hard- to-treat cancers (extracted from patent WO2019099298A1, compound 1) .

HY-142682

SCP1-IN-1	Others	Neurological Disease Cancer
SCP1-IN-1 (compound SH T-62) is a potent and selective covalent inhibitor against SCP1. SCP1-IN-1 promotes REST degradation and reduces transcriptional activity. A high level of REST protein drives the tumor growth in some glioblastoma cells. SCP1-IN-1 has the potential for the research of glioblastoma whose growth is driven by REST transcription activity .

HY-142683

SCP1-IN-2	Others	Neurological Disease Cancer
SCP1-IN-2 (Compound SH T-65) is a potent and selective covalent inhibitor against SCP1. SCP1-IN-2 promotes REST degradation and reduces transcriptional activity. A high level of REST protein drives the tumor growth in some glioblastoma cells. SCP1-IN-2 has the potential for the research of glioblastoma whose growth is driven by REST transcription activity .

HY-N2509

Iristectorigenin B Iristectrigenin B	LXR	Cardiovascular Disease
Iristectorigenin B (Iristectrigenin B) is a liver X receptor (LXR) modulator. Iristectrigenin B stimulates the transcriptional activity of both LXR-α and LXR-β .

HY-100277

Mifobate 1 Publications Verification SR-202	PPAR	Metabolic Disease
Mifobate (SR-202) is a potent and specific PPARγ antagonist. Mifobate (SR-202) selectively inhibits Thiazolidinedione (TZD)-induced PPARγ transcriptional activity (IC₅₀=140 μM). Mifobate (SR-202) does not affect basal or ligand-stimulated transcriptional activity of PPARα, PPARβ, or the farnesoid X receptor (FXR). Mifobate (SR-202) shows antiobesity and antidiabetic effects .

HY-145431

(S)-GSK1379725A	Epigenetic Reader Domain Parasite	Infection
(S)-GSK1379725A (compound AU1) is a selective *bromodomain and PHD finger containing transcription* factor (BPTF) bromodomain inhibitor with a K_d** of 2.8 μM. (S)-GSK1379725A shows to be selective for BPTF over BRD4 bromodomain. (S)-GSK1379725A shows antimalarial activity .

HY-111411

IZCZ-3

2 Publications Verification

c-Myc Autophagy Cancer

IZCZ-3 is a potent c-MYC transcription inhibitor with antitumor activity .

IZCZ-3 2 Publications Verification	c-Myc Autophagy	Cancer
IZCZ-3 is a potent c-MYC transcription inhibitor with antitumor activity .

HY-15870

SR 11302 5 Publications Verification	AP-1	Inflammation/Immunology Cancer
SR 11302 is an activator protein-1 (AP-1) transcription factor inhibitor. SR 11302 is a retinoid that specifically inhibits AP-1 activity without activating the transcription of retinoic acid response element (RARE) .

HY-108441

CCT031374 hydrobromide	β-catenin	Cancer
CCT 031374 hydrobromid is a potent inhibitor of *β-catenin/transcription* factor (TCF)** complex signaling. CCT031374 inhibits TCF-dependent transcription of genes of Wnt signaling pathway. CCT 031374 has antitumor activity .

HY-N10457

Norstictic acid	Bacterial	Infection Cancer
Norstictic acid is a potent and selective allossteric transcriptional regulator. Norstictic acid shows anticancer activity. Norstictic acid shows antioxidant activity and antimicrobial activity .

HY-116940

Sm4	Others	Cancer
Sm4 is a SOX18 inhibitor. Sm4 shows SOX18-DNA binding inhibitory activity. Sm4 selectively affects SOX18 transcriptional output in vitro. Sm4 blocks SoxF transcriptional activity in vivo. Sm4 can be used for cancer metastasis and vascular cancers research .

HY-103223

Phortress

NSC 710305
Cytochrome P450 Cancer

Phortress is a high affinity AhR ligand that elicits antitumor activity by inducing transcription of CYP1A1 .

Phortress NSC 710305	Cytochrome P450	Cancer
Phortress is a high affinity AhR ligand that elicits antitumor activity by inducing transcription of CYP1A1 .

HY-12270

T-5224 45+ Cited Publications	AP-1 MMP	Others
T-5224 is a transcription factor c-Fos/activator protein (AP)-1 inhibitor with anti-inflammatory effects, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors. T-5224 inhibits the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription .

HY-153347

JY-2	Others	Metabolic Disease
JY-2 is a moderately selective and orally active Forkhead transcription factor forkhead box O1 (FoxO1) inhibitor that inhibits FoxO1 transcriptional activity with an IC₅₀ of 22 μM. JY-2 shows moderate inhibition against FoxO3a and FoxO4. JY-2 shows anti-diabetic activity .

HY-112920

TM-25659

Others Metabolic Disease

TM-25659 is a transcriptional co-activator with PDZ-binding motif (TAZ) modulator. Anti-osteoporotic and anti-obesity activities .

TM-25659	Others	Metabolic Disease
TM-25659 is a transcriptional co-activator with PDZ-binding motif (TAZ) modulator. Anti-osteoporotic and anti-obesity activities .

HY-14422

SR1078 10+ Cited Publications	ROR	Cancer
SR1078 is a selective agonist of retinoic acid receptor-related orphan receptor α/γ (RORα/RORγ). SR1078 directly binds to the ligand binding domain of RORα and RORγ and increases the transcriptional activity of these receptors, leading to stimulation of RORα/γ target gene transcription .

HY-101464

ML329 5 Publications Verification	Others	Others
ML329 is a micropthalmia-associated transcription factor (MITF) inhibitor, which inhibits TRPM-1 promoter activity with an IC₅₀ of 1.2 μM.

HY-135732

SK33	Androgen Receptor	Cancer
SK33, a trifluoromethylated enobosarm analog, is a potent, and tissue selective anti-androgen. SK33reduces androgen receptor (AR) transcriptional activity .

HY-156673

m-Se3

c-Myc Cancer

m-Se3 is a potent and selective c-MYC transcription inhibitor that can inhibit tumor growth and has anti-cancer activity .

m-Se3	c-Myc	Cancer
m-Se3 is a potent and selective c-MYC transcription inhibitor that can inhibit tumor growth and has anti-cancer activity .

HY-B0167

Salicylic acid 5+ Cited Publications 2-Hydroxybenzoic acid	COX Autophagy Mitophagy Apoptosis Endogenous Metabolite	Inflammation/Immunology Cancer
Salicylic acid (2-Hydroxybenzoic acid) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation .

HY-142100

Licoagrochalcone C	NF-κB	Inflammation/Immunology
Licoagrochalcone C, a flavonoid, reveals efficacious inhibitory activity on NF-κB transcription. Licoagrochalcone C shows significant inhibitory activity on LPS (HY-D1056)-induced NO production .

HY-15865

FR901463

Others Cancer

FR901463 is a potent anti-cancer agent and can be used for cancer research. FR901463 enhances the transcriptional activity of the promoter of SV40 DNA virus .

FR901463	Others	Cancer
FR901463 is a potent anti-cancer agent and can be used for cancer research. FR901463 enhances the transcriptional activity of the promoter of SV40 DNA virus .

HY-15681

Senexin A 5+ Cited Publications	CDK	Cancer
Senexin A is an inhibitor of CDK8/19 (IC₅₀: 280 nM, CDK8) and an inhibitor downstream of p21 transcription. It only inhibits p21-induced transcription but does not inhibit other biological effects of p21. Senexin A inhibits CMV-GFP induction as well as the p21 stimulatory activity of the consensus NF-κB-dependent promoters .

HY-15681A

Senexin A hydrochloride	CDK	Cancer
Senexin A hydrochloride is an inhibitor of CDK8/19 (IC₅₀: 280 nM, CDK8) and an inhibitor downstream of p21 transcription. It only inhibits p21-induced transcription but does not inhibit other biological effects of p21. Senexin A hydrochloride inhibits CMV-GFP induction as well as the p21 stimulatory activity of the consensus NF-κB-dependent promoters .

HY-19987

BML-284 20+ Cited Publications	Wnt	Cancer
BML-284 is a potent and cell-permeable Wnt signaling activator. BML-284 induces TCF-dependent transcriptional activity with an EC₅₀ of 700 nM .

HY-N4182

Licochalcone E	Akt p38 MAPK Autophagy	Inflammation/Immunology
Licochalcone E, a flavonoid compound isolated from Glycyrrhiza uralensis, inhibits NF-κB and AP-1 transcriptional activity through the inhibition of AKT and MAPK activation .

HY-19987A

BML-284 hydrochloride	Wnt	Cancer
BML-284 hydrochloride is a potent and cell-permeable Wnt signaling activator. BML-284 induces TCF-dependent transcriptional activity with an EC₅₀ of 700 nM .

HY-114646

TMC-205	Endogenous Metabolite	Cancer
TMC-205 is a natural fungal metabolite with antiproliferative activity against cancer cell lines. TMC-205 is a transcriptional up-regulator of SV40 promoter .

HY-161127

NT-B2R

c-Myc Cancer

NT-B2R is a potent MYC inhibitor. NT-B2R inhibited MYC transcriptional activity and cell proliferation .

NT-B2R	c-Myc	Cancer
NT-B2R is a potent MYC inhibitor. NT-B2R inhibited MYC transcriptional activity and cell proliferation .

HY-115672

KS15 1 Publications Verification	Cryptochrome	Cancer
KS15 is an inhibitor of the interactions between cryptochromes (CRYs: CRY1 and CRY2) and the CLOCK:BMAL1 heterodimer. KS15 impairs the feedback actions of CRYs on E-box-dependent transcription (EC₅₀=4.9 μM) by CLOCK:BMAL1 heterodimer, an indispensable transcriptional regulator of the mammalian circadian clock. Anti-proliferative activity .

HY-12484

BMH-21 5 Publications Verification	DNA/RNA Synthesis	Cancer
BMH-21 is a first-in-class DNA intercalator which inhibits RNA polymerase I (Pol I) transcription. BMH-21 possesses anticancer activity .

HY-114740

β-Naphthoflavone 1 Publications Verification 5,6-Benzoflavone; beta-NF	Aryl Hydrocarbon Receptor Apoptosis	Neurological Disease Cancer
β-Naphthoflavone is a non-carcinogenic AhR agonist as a positive control for the induction of AhR transcriptional activity . β-Naphthoflavone inhibits hydrogen peroxide-induced apoptosis .

HY-126037

(±)-ML 209 1 Publications Verification	ROR	Inflammation/Immunology
(±)-ML 209 (compound 4n), a diphenylpropanamide, is a retinoic acid-related orphan receptor RORγ antagonist with an IC₅₀ of 1.1 μM. (±)-ML 209 inhibits RORγt transcriptional activity with an IC₅₀ of 300 nM in HEK293t cells. (±)-ML 209 inhibits the transcriptional activity of RORγt, but not RORα in cells. (±)-ML 209 selectively inhibits murine Th17 cell differentiation without affecting the differentiation of naïve CD4 ⁺ T cells into other lineages, including Th1 and regulatory T cells .

HY-132205

DS45500853	Estrogen Receptor/ERR	Metabolic Disease
DS45500853 is an estrogen-related receptor α (ERRα) agonist. DS45500853 inhibits the binding between receptor-interacting protein 140 (RIP140) corepressor peptide (10 nM) and GST-ERRα ligand-binding domain (LBD; 1.2 μM) with an IC₅₀ value of 0.80 μM. DS45500853 can be used for the research of metabolic disorders, including type 2 diabetes mellitus (T2DM) .

HY-15484

Pifithrin-α hydrobromide 50+ Cited Publications Pifithrin hydrobromide; PFTα hydrobromide	MDM-2/p53 Aryl Hydrocarbon Receptor Ferroptosis Apoptosis	Cancer
Pifithrin-α hydrobromide is a p53 inhibitor which blocks its transcriptional activity and prevents cells from apoptosis. Pifithrin-α hydrobromide is also an aryl hydrocarbon receptor (AhR) agonist.

HY-100760

Toxoflavin 3 Publications Verification Xanthothricin; Toxoflavine; PKF-118-310
Toxoflavin (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex, also acts as an inhibitor of KDM4A, with antitumor activity . Antibiotic properties.

HY-122234

VPC-18005	Others	Cancer
VPC-18005 inhibits ERG-induced transcription and interacts directly with the ERG-ETS domain, and disrupts the ERG binding to DNA. VPC-18005 is a potent inhibitor of luciferase activity .

HY-117726

WAY-169916	Estrogen Receptor/ERR NF-κB	Inflammation/Immunology
WAY-169916 is a pathway-selective ligand of ER (estrogen receptor) that acts by inhibiting NF-kB transcriptional activity. WAY-169916 has potent anti-inflammatory effect .

HY-16401

Zalypsis PM00104	Apoptosis	Cancer
Zalypsis (PM00104) has anti-tumor activity. Zalypsis binds to DNA and shows cytotoxicity. Zalypsis inhibits cell cycle and transcription, and leads to double stranded DNA breaks .

HY-N0907

Ginsenoside Rg6	NF-κB Apoptosis	Inflammation/Immunology Cancer
Ginsenoside Rg6 inhibits TNF-α-induced NF-κB transcriptional activity with an IC₅₀ of 29.34 μM in HepG2 cells. Ginsenoside Rg6 also exhibits apoptosis-inducing effect.

HY-B0167S

Salicylic acid-d6 2-Hydroxybenzoic acid-d₆	COX Autophagy Mitophagy Apoptosis	Inflammation/Immunology Cancer
Salicylic acid-d₆ is a deuterium labeled Salicylic acid. Salicylic acid inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation[1].

HY-N0268

Irisflorentin	NO Synthase	Inflammation/Immunology
Irisflorentin, a naturally occurring isoflavone, is an abundant active constituent in Belamcanda chinensis. Irisflorentin markedly reduces the transcriptional and translational levels of inducible nitric oxide synthase (iNOS) as well as the production of NO. Anti-inflammatory activity .

HY-135145

Limantrafin 5 Publications Verification CB-103	Notch	Cancer
Limantrafin (CB-103) is a first-in-class, orally active protein-protein interaction (PPI) inhibitor of the NOTCH transcriptional activation complex. Limantrafin has anti-tumor activity .

HY-10172

IMD-0354 10+ Cited Publications IKK2 Inhibitor V	IKK	Cancer
IMD-0354 (IKK2 Inhibitor V) is a selective IKKβ inhibitor which inhibits NF-κB activity . IMD0354 inhibits TNF-α induced NF-κB transcription activity with an IC₅₀ of 1.2 uM .

HY-155338

SWTX-143	YAP	Cancer
SWTX-143 is a novel covalent YAP/TAZ-TEAD inhibitor that binds to the palmitoylation pocket of all four TEAD isoforms. SWTX-143 causes irreversible and specific inhibition of the transcriptional activity of YAP/TAZ-TEAD and shows antitumor activity .

Cat. No.	Product Name

HY-L045

Oxygen Sensing Compound Library

2507 compounds

Oxygen homeostasis regulation is the most fundamental cellular process for adjusting physiological oxygen variations, and its irregularity leads to various human diseases, including cancer. Hypoxia is closely associated with cancer development, and hypoxia/oxygen-sensing signaling plays critical roles in the modulation of cancer progression.

Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. A variety of HF-1 target genes have been identified thus far which encode proteins that play key roles in critical developmental and physiological processes including angiogenesis/vascular remodeling, erythropoiesis, glucose transport, glycolysis, iron transport, and cell proliferation/survival.

HIF-1 is a heterodimeric transcription factor consisting of a constitutively expressed β-subunit and an oxygen-regulated α-subunit. The unique feature of HIF-1 is the regulation of HIF-1α expression and activity based upon the cellular O₂ concentration. Under normoxic conditions, hydroxylation of HIF-1α on these different proline residues is essential for HIF proteolytic degradation by promoting interaction with the von Hippel-Lindau tumor-suppressor protein (pVHL) through hydrogen bonding to the hydroxyproline-binding pocket in the pVHL β-domain. As oxygen levels decrease, hydroxylation of HIF decreases; HIF-1α then no longer binds pVHL, and becomes stabilized, allowing more of the protein to translocate to the cell’s nucleus, where it acts as a transcription factor, upregulating (often within minutes) the production of proteins that stimulate blood perfusion in tissues and thus tissue oxygenation.

MCE offers a unique collection of 2507 oxygen sensing related compounds targeting HIF/HIF Prolyl-Hydroxylase, MAPK/ERK, PI3K/AKT signaling pathways, etc. MCE Oxygen Sensing Compound Library is a useful tool to study hypoxia, oxidative stress and discover new anti-cancer drugs.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2509

Iristectorigenin B Iristectrigenin B	Cardiovascular Disease Natural Products Iridaceae Classification of Application Fields Source classification Phenols Polyphenols Plants Belamcanda chinensis (Linn.) Redouté Disease Research Fields	LXR
Iristectorigenin B (Iristectrigenin B) is a liver X receptor (LXR) modulator. Iristectrigenin B stimulates the transcriptional activity of both LXR-α and LXR-β .

HY-N10457

Norstictic acid	Infection Classification of Application Fields Usnea diffracta Vain. Ketones, Aldehydes, Acids Source classification Plants Disease Research Fields Usneaceae Cancer	Bacterial
Norstictic acid is a potent and selective allossteric transcriptional regulator. Norstictic acid shows anticancer activity. Norstictic acid shows antioxidant activity and antimicrobial activity .

HY-B0167

Salicylic acid 5+ Cited Publications 2-Hydroxybenzoic acid	Structural Classification Classification of Application Fields Anti-aging Source classification Plants Endogenous metabolite Agricultural Research Monophenols other families Microorganisms Ketones, Aldehydes, Acids Phenols Phytohormone Inflammation/Immunology Disease Research Fields Cancer	COX Autophagy Mitophagy Apoptosis Endogenous Metabolite
Salicylic acid (2-Hydroxybenzoic acid) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation .

HY-N12011

11-Oxoisomogroside V	Structural Classification Polysaccharides Source classification Cucurbitaceae Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang Plants Saccharides	PGC-1α
11-Oxoisomogroside V (compound 3) is a cucurbitacin isolated from the crude extract of Luo Han Guo. 11-Oxoisomogroside V activates the transcriptional activity of PGC-1α. In the luciferase experiment, the results showed that 10 μM and 20 μM 11-Oxoisomogroside V could increase the luciferase activity to 133.79% and 143.81% .

HY-142100

Licoagrochalcone C	Structural Classification Glycyrrhiza glabra Linn. Flavonoids Leguminosae Source classification Plants Other Flavonoids	NF-κB
Licoagrochalcone C, a flavonoid, reveals efficacious inhibitory activity on NF-κB transcription. Licoagrochalcone C shows significant inhibitory activity on LPS (HY-D1056)-induced NO production .

HY-N4182

Licochalcone E	Chalcones Flavonoids Classification of Application Fields Leguminosae Source classification Plants Inflammation/Immunology Disease Research Fields Glycyrrhiza uralensis Fisch.	Akt p38 MAPK Autophagy
Licochalcone E, a flavonoid compound isolated from Glycyrrhiza uralensis, inhibits NF-κB and AP-1 transcriptional activity through the inhibition of AKT and MAPK activation .

HY-114646

TMC-205	Alkaloids Microorganisms Classification of Application Fields Source classification Disease Research Fields Indole Alkaloids Cancer	Endogenous Metabolite
TMC-205 is a natural fungal metabolite with antiproliferative activity against cancer cell lines. TMC-205 is a transcriptional up-regulator of SV40 promoter .

HY-N0907

Ginsenoside Rg6	Panax ginseng C. A. Meyer Triterpenes Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Inflammation/Immunology Araliaceae	NF-κB Apoptosis
Ginsenoside Rg6 inhibits TNF-α-induced NF-κB transcriptional activity with an IC₅₀ of 29.34 μM in HepG2 cells. Ginsenoside Rg6 also exhibits apoptosis-inducing effect.

HY-N0268

Irisflorentin	Flavonoids Iridaceae Classification of Application Fields Source classification Plants Belamcanda chinensis (Linn.) Redouté Inflammation/Immunology Disease Research Fields Isoflavones	NO Synthase
Irisflorentin, a naturally occurring isoflavone, is an abundant active constituent in Belamcanda chinensis. Irisflorentin markedly reduces the transcriptional and translational levels of inducible nitric oxide synthase (iNOS) as well as the production of NO. Anti-inflammatory activity .

HY-N11994

Aloeresin G	Structural Classification Monophenols Liliaceae Source classification Phenols Aloe vera (L.) Burm. f. Plants	TNF Receptor
Aloeresin G is a chromone glycoside that can be isolated from Aloe. Aloeresin G has a weak inhibitory effect on TNFα-induced NF-κB transcriptional activity, with an IC 50 value of 40.02 μM .

HY-N0906

Ginsenoside Rk3	Cardiovascular Disease Panax ginseng C. A. Meyer Triterpenes Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Araliaceae	NF-κB
Ginsenoside Rk3 is present in the roots Panax ginseng herbs. Ginsenoside Rk3 significantly inhibits TNF-α-induced NF-κB transcriptional activity, with an IC₅₀ of 14.24±1.30 μM in HepG2 cells.

HY-N11892

7-O-Methylaloesinol	Structural Classification Natural Products Liliaceae Source classification Aloe vera (L.) Burm. f. Plants	NF-κB
7-O-Methylaloesinol is a chromone derivative. 7-O-Methylaloesinol shows significant inhibitory effects against TNFα-induced NF-κB transcriptional activity with an IC₅₀ value of 29.07 μM .

HY-B0167R

Salicylic acid (Standard) 2-Hydroxybenzoic acid (Standard)	Structural Classification Classification of Application Fields Anti-aging Source classification Plants Endogenous metabolite Agricultural Research other families Ketones, Aldehydes, Acids Phenols Phytohormone Inflammation/Immunology Disease Research Fields Cancer	COX Autophagy Mitophagy Apoptosis Endogenous Metabolite
Salicylic acid (Standard) is the analytical standard of Salicylic acid. This product is intended for research and analytical applications. Salicylic acid (2-Hydroxybenzoic acid) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation .

HY-113414

Deoxycorticosterone 2 Publications Verification	Structural Classification Classification of Application Fields Source classification Disease markers Other Diseases Endocrine diseases Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite Mineralocorticoid Receptor
Deoxycorticosterone is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as an aldosterone precursor. Deoxycorticosterone is an agonist for O. mykiss mineralocorticoid receptor (rtMR) transcription with EC₅₀ of 0.16 nM . Deoxycorticosterone could acts as an immune stimulator in fish .

HY-N10016

Chlorogenic acid butyl ester	Structural Classification Lysimachia davurica Ledeb. Source classification Phenols Polyphenols Plants Primulaceae	Tyrosinase
Chlorogenic acid butyl ester, a caffeoylquinic acid, is a potent melanogenesis inhibitor. Chlorogenic acid butyl ester inhibits the expression of microphtalmia-associated transcription factor (MITF), tyrosinase, tyrosinerelated protein 1 (TRP-1), and TRP-2. Chlorogenic acid butyl ester also shows antioxidant activity .

HY-119970

Helenalin 4 Publications Verification	Structural Classification other families Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Inflammation/Immunology Disease Research Fields	NF-κB
Helenalin is an anti-inflammatory sesquiterpene lactone. Helenalin selectively inhibits transcription factor NF-κB by directly targeting p65. Helenalin has alkylating activity, targets the cysteine sulfhydryl groups in the p65 subunit of NF-κB, thereby inhibits its DNA binding .

HY-B0167A

Sodium Salicylate 5+ Cited Publications Salicylic acid sodium salt; 2-Hydroxybenzoic acid sodium salt	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Asclepiadaceae Phenols Plants Periploca sepium Bunge Inflammation/Immunology Disease Research Fields Cancer	COX NF-κB Ribosomal S6 Kinase (RSK) Autophagy Apoptosis Endogenous Metabolite
Sodium Salicylate (Salicylic acid sodium salt) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation . Sodium Salicylate is also a S6K inhibitor.Sodium Salicylate is a NF-κB inhibitor that decreases inflammatory gene expression and improves repair in aged muscle .

HY-N0279

Cardamonin 5+ Cited Publications Cardamomin; Alpinetin chalcone	Structural Classification Chalcones Flavonoids Classification of Application Fields Source classification Phenols Polyphenols Boesenbergia rotunda Plants Disease Research Fields Cancer Zingiberaceae	NF-κB STAT Wnt β-catenin Bcl-2 Family Apoptosis
Cardamonin can be found from cardamom, and target various signaling molecules, transcriptional factors, cytokines and enzymes. Cardamonin can inhibit mTOR, NF-κB, Akt, STAT3, Wnt/β-catenin and COX-2. Cardamonin shows anticancer, anti-inflammatory, antimicrobial and antidiabetic activities .

HY-B1192

Estradiol benzoate 10+ Cited Publications β-Estradiol 3-benzoate; 17β-Estradiol 3-benzoate	Classification of Application Fields Disease Research Fields Cancer	Estrogen Receptor/ERR HBV Bcl-2 Family
Estradiol benzoate (β-Estradiol 3-benzoate) is a HBx protein inhibitor and inhibits androgen and hepatitis B virus (HBV) transcription, replication. Estradiol benzoate shows antifertility effects, anti- Toxoplasma gondii activity and can improve memory behavior of Ovariectomy (Ovx) female mice .

HY-N0041

Ginsenoside Rb3 Gypenoside IV	Panax ginseng C. A. Meyer Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields Araliaceae Cancer	NF-κB COX NO Synthase
Ginsenoside Rb3 is extracted from steamed Panax ginseng C. A. Meyer. Ginsenoside Rb3 exhibits inhibitory effect on TNFα-induced NF-κB transcriptional activity with an IC₅₀ of 8.2 μM in 293T cell lines. Ginsenoside Rb3 also inhibits the induction of COX-2 and iNOS mRNA.

HY-129113

α-Chaconine	Alkaloids Piperidine Alkaloids Zea mays L. Pyrrole Alkaloids Classification of Application Fields Gramineae Source classification Plants Disease Research Fields Inflammation/Immunology	COX
α-Chaconine inhibits the expressions of COX-2, IL-1β, IL-6, and TNF-α at the transcriptional level. α-Chaconine inhibits the LPS-induced expressions of iNOS and COX-2 at the protein and mRNA levels and their promoter activities in RAW 264.7 macrophages. Anti-inflammatory effects .

HY-N0292

Oleuropein 1 Publications Verification	Cardiovascular Disease Structural Classification Classification of Application Fields Anti-aging Source classification Plants Burseraceae Iridoids Canarium album (Lour.) Rauesch. Terpenoids Phenols Polyphenols Inflammation/Immunology Disease Research Fields Cancer	Cytochrome P450 PPAR Apoptosis
Oleuropein, found in olive leaves and oil, exerts antioxidant, anti-inflammatory and anti-atherogenic effects through direct inhibition of PPARγ transcriptional activity . Oleuropein induces apoptosis in breast cancer cells via the p53-dependent pathway and through the regulation of Bax and Bcl2 genes. Oleuropein also inhibits aromatase .

HY-N4126

6-Demethoxytangeretin	Flavonoids other families Neurological Disease Classification of Application Fields Flavones Source classification Rutaceae Plants Inflammation/Immunology Disease Research Fields Citrus reticulata Blanco Cancer	Anaplastic lymphoma kinase (ALK)
6-Demethoxytangeretin is a citrus flavonoid isolated from Citrus reticulata. 6-Demethoxytangeretin exerts anti-inflammatory activity and anti-allergic activity, suppresses production and gene expression of interleukin-6 in human mast cell-1 via anaplastic lymphoma kinase (ALK) and mitogen-activated protein kinase (MAPK) pathways . 6-Demethoxytangeretin facilitates the CRE-mediated transcription associated with learning and memory in cultured hippocampal neurons .

HY-110028

Leelamine hydrochloride	Structural Classification other families Classification of Application Fields Pinaceae Terpenoids Source classification Diterpenoids Plants Disease Research Fields Pinus massoniana Lamb. Endocrinology	Cannabinoid Receptor Fatty Acid Synthase (FASN) Androgen Receptor
Leelamine hydrochloride is a tricyclic diterpene molecule that is extracted from the bark of pine trees . Leelamine hydrochloride is a cannabinoid receptor type 1 (CB1) agonist and a inhibitor of SREBP1-regulated fatty acid/lipid synthesis in prostate cancer cells that is not affected by androgen receptor status. Leelamine hydrochloride suppresses transcriptional activity of androgen receptor, which is known to regulate fatty acid synthesis ^[2,3].

HY-50936

Trabectedin 3 Publications Verification Ecteinascidin 743; ET-743	Alkaloids Structural Classification Classification of Application Fields Animals Source classification Marine natural products Other marine organisms Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields	Reactive Oxygen Species Apoptosis
Trabectedin (Ecteinascidin 743; ET-743) is a tetrahydroisoquinoline alkaloid with potent antitumor activity. Trabectedin binds to the minor groove of DNA, blocks transcription of stress-induced proteins, induces DNA backbone cleavage and cancer cells apoptosis, and increases the generation of ROS in MCF-7 and MDA-MB-453 cells. Trabectedin has the potential for soft tissue sarcoma and ovarian cancer research .

HY-N10768

1-Dehydro-[10]-gingerdione	Structural Classification Monophenols Source classification Phenols Plants Zingiberaceae	IKK NF-κB
1-Dehydro-[10]-gingerdione directly inhibits IKKβ activity by targeting the activation loop of IKKβ, thus disrupting IKKβ-catalysed IκBα phosphorylation in macrophages stimulated with agonists. 1-Dehydro-[10]-gingerdione inhibits LPS (HY-D1056)-induced NF-κB transcriptional activity. 1-Dehydro-[10]-gingerdione has the potential for NF-κB-associated inflammation and autoimmune disorders research .

HY-N0005

Curcumin Maximum Cited Publications 62 Publications Verification Diferuloylmethane; Natural Yellow 3; Turmeric yellow	Structural Classification Classification of Application Fields Anti-aging Source classification Plants Food Research Microorganisms Sunscreen Phenols Polyphenols Pigments Cosmetic Research Curcuma longa Disease Research Fields Cancer Zingiberaceae	Histone Acetyltransferase Epigenetic Reader Domain Keap1-Nrf2 Autophagy Mitophagy Influenza Virus Ferroptosis
Curcumin (Diferuloylmethane), a natural phenolic compound, is a p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. Curcumin shows inhibitory effects on NF-κB and MAPKs, and has diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification.

HY-N2025

Oroxin A	Flavonoids Classification of Application Fields Flavones Source classification Metabolic Disease Plants Bignoniaceae Oroxylum indicum (Linn.) Bentham ex Kurz Disease Research Fields	PPAR Glucosidase
Oroxin A is the major component of an ethanol-water Oroxylum indicum (L.) Kurz (Bignoniaceae) seed extract (OISE). Oroxin A acts as a partial PPARγ agonist that can activate PPARγ transcriptional activation. Oroxin A activates PPARγ by docking into the PPARγ protein ligand-binding domain. Oroxin A also exhibits an inhibitory activity against α-glucosidase and an antioxidant capacity . Oroxin A exerts anti-breast cancer effects by inducing ER stress-mediated senescence .

HY-N11996

Aloenin aglycone	Structural Classification Liliaceae Source classification Phenols Polyphenols Aloe vera (L.) Burm. f. Plants	NO Synthase NF-κB
Aloenin aglycone (compound 13) is an NF-κB inhibitor that can be isolated from aloe exudate. Aloenin aglycone inhibits TNFα-induced NF-κB transcriptional activity (IC₅₀: 18.7 μM). Aloenin aglycone (10 μM) also reduced inducible nitric oxide synthase (iNOS) and intercellular adhesion molecule 1 (ICAM-1) gene expression after treatment of HepG2 cells with 10 ng/mL TNFα .

HY-N0041R

Ginsenoside Rb3 (Standard) Gypenoside IV (Standard)	Panax ginseng C. A. Meyer Structural Classification Classification of Application Fields Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields Araliaceae Cancer	NF-κB COX NO Synthase
Ginsenoside Rb3 (Standard) is the analytical standard of Ginsenoside Rb3. This product is intended for research and analytical applications. Ginsenoside Rb3 is extracted from steamed Panax ginseng C. A. Meyer. Ginsenoside Rb3 exhibits inhibitory effect on TNFα-induced NF-κB transcriptional activity with an IC₅₀ of 8.2 μM in 293T cell lines. Ginsenoside Rb3 also inhibits the induction of COX-2 and iNOS mRNA.

HY-B0239

Chloramphenicol 5+ Cited Publications	Structural Classification Classification of Application Fields Anti-aging Source classification Antibacterial Disease Research Endogenous metabolite Other Antibiotics Infection Human Gut Microbiota Metabolites Plant Cell Culture Microorganisms Antibiotics Resistance Selection Animal Husbandry Anticancer Disease Research Fields Cancer	Antibiotic Bacterial HIF/HIF Prolyl-Hydroxylase VEGFR Autophagy Apoptosis Beclin1 JNK Akt MMP
Chloramphenicol is an orally active, potent and broad-spectrum antibiotic. Chloramphenicol shows antibacterial activity. Chloramphenicol represses the oxygen-labile transcription factor and hypoxia inducible factor-1 alpha (HIF-1α) in hypoxic A549 and H1299 cells. Chloramphenicol suppresses the mRNA levels of vascular endothelial growth factor (VEGF) and glucose transporter 1, eventually decreasing VEGF release. Chloramphenicol can be used for anaerobic infections and lung cancer research .

HY-N8146

Bruceantinol	Infection Triterpenes Simaroubaceae Classification of Application Fields Brucea antidysenterica J.F.Mill. Terpenoids Source classification Plants Disease Research Fields Cancer Brucea javanica (L.) Merr.	STAT
Bruceantinol, a quassinoid isolated from Brucea javanica, inhibits pepper mottle virus in pepper . Bruceantinol is a STAT3 inhibitor demonstrating potent antitumor activity in in vitro and in vivo human colorectal cancer (CRC) models. Bruceantinol strongly inhibits STAT3 DNA-binding ability (IC₅₀=2.4 pM), blocks the constitutive and IL-6-induced STAT3 activation, and suppresses transcription of MCL-1, PTTG1, survivin and c-Myc .

HY-N10330

7-Hydroxyneolamellarin A	Structural Classification Animals Source classification Phenols	HIF/HIF Prolyl-Hydroxylase VEGFR
7-Hydroxyneolamellarin A is a natural product that could be derived from sponge Dendrilla nigra. 7-Hydroxyneolamellarin A is a potent hypoxia-inducible factor-1α (HIF-1α) inhibitor. 7-Hydroxyneolamellarin A attenuates the accumulation of hypoxia-inducible factor-1α (HIF-1α) protein and inhibits vascular epidermal growth factor (VEGF) transcriptional activity. 7-Hydroxyneolamellarin A can be used in research of cancer .

HY-13755

Sulforaphane 30+ Cited Publications	Structural Classification Natural Products other families Classification of Application Fields Source classification Plants Inflammation/Immunology Disease Research Fields	HDAC Keap1-Nrf2 Apoptosis Bcl-2 Family Caspase Reactive Oxygen Species
Sulforaphane is an orally active inducer of the Keap1/Nrf2/ARE pathway. Sulforaphane promotes the transcription of tumor-suppressing proteins and effectively inhibits the activity of HDACs. Through the activation of the Keap1/Nrf2/ARE pathway and further induction of HO-1 expression, Sulforaphane protects the heart. Sulforaphane suppresses high glucose-induced pancreatic cancer through AMPK-dependent signal transmission. Sulforaphane exhibits both anticancer and anti-inflammatory properties .

HY-N0043

Ginsenoside Rd Gypenoside VIII	Cardiovascular Disease Panax ginseng C. A. Meyer Triterpenes Classification of Application Fields Terpenoids Source classification Plants Endogenous metabolite Disease Research Fields Araliaceae Cancer	NF-κB COX Calcium Channel Cytochrome P450 Endogenous Metabolite
Ginsenoside Rd inhibits TNFα-induced NF-κB transcriptional activity with an IC₅₀ of 12.05±0.82 μM in HepG2 cells. Ginsenoside Rd inhibits expression of COX-2 and iNOS mRNA. Ginsenoside Rd also inhibits Ca ²⁺ influx. Ginsenoside Rd inhibits CYP2D6, CYP1A2, CYP3A4, and CYP2C9, with IC₅₀s of 58.0±4.5 μM, 78.4±5.3 μM, 81.7±2.6 μM, and 85.1±9.1 μM, respectively.

HY-N0043R

Ginsenoside Rd (Standard) Gypenoside VIII (Standard)	Cardiovascular Disease Panax ginseng C. A. Meyer Structural Classification Classification of Application Fields Terpenoids Source classification Plants Endogenous metabolite Disease Research Fields Araliaceae Cancer	NF-κB COX Calcium Channel Cytochrome P450 Endogenous Metabolite
Ginsenoside Rd (Standard) is the analytical standard of Ginsenoside Rd. This product is intended for research and analytical applications. Ginsenoside Rd inhibits TNFα-induced NF-κB transcriptional activity with an IC₅₀ of 12.05±0.82 μM in HepG2 cells. Ginsenoside Rd inhibits expression of COX-2 and iNOS mRNA. Ginsenoside Rd also inhibits Ca ²⁺ influx. Ginsenoside Rd inhibits CYP2D6, CYP1A2, CYP3A4, and CYP2C9, with IC₅₀s of 58.0±4.5 μM, 78.4±5.3 μM, 81.7±2.6 μM, and 85.1±9.1 μM, respectively.

Cat. No.	Product Name	Chemical Structure

HY-B0167S

Salicylic acid-d6
Salicylic acid-d₆ is a deuterium labeled Salicylic acid. Salicylic acid inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation[1].

HY-50936S

Trabectedin-d3

Trabectedin D3 (Ecteinascidin 743 D3) is deuterium labeled Trabectedin. Trabectedin is a tetrahydroisoquinoline alkaloid with potent antitumor activity. Trabectedin binds to the minor groove of DNA, blocks transcription of stress-induced proteins, induces DNA backbone cleavage and cancer cells apoptosis, and increases the generation of ROS in MCF-7 and MDA-MB-453 cells. Trabectedin has tje potential for soft tissue sarcoma and ovarian cancer treatment .

HY-W751835

Baloxavir-d4

15+ Cited Publications

Baloxavir-d₄ (Baloxavir acid-d₄; S-033447-d₄) is the deuterium-labeled Baloxavir (HY-109025A). Baloxavir-d₄ (Baloxavir-d₄ acid), derived from the proagent Baloxavir-d₄ marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir-d₄ inhibits viral RNA transcription and replication and has potently antiviral activity .

HY-100760S

Toxoflavin-13C4
Toxoflavin- ¹³C₄ is the ¹³C-labeled Toxoflavin. Toxoflavin (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex, also acts as an inhibitor of KDM4A, with antitumor activity[1][2]. Antibiotic properties.

HY-109025AS

Baloxavir-d5
Baloxavir-d₅ is deuterium labeled Baloxavir. Baloxavir (Baloxavir acid), derived from the proagent Baloxavir marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir inhibits viral RNA transcription and replication and has potently antiviral activity[1][2].

HY-B0239S2

Threo-Chloramphenicol-d6

Threo-Chloramphenicol-d₆ is the deuterium labeled Chloramphenicol[1]. Chloramphenicol is an orally active, potent and broad-spectrum antibiotic. Chloramphenicol shows antibacterial activity. Chloramphenicol represses the oxygen-labile transcription factor and hypoxia inducible factor-1 alpha (HIF-1α) in hypoxic A549 and H1299 cells. Chloramphenicol suppresses the mRNA levels of vascular endothelial growth factor (VEGF) and glucose transporter 1, eventually decreasing VEGF release. Chloramphenicol can be used for anaerobic infections and lung cancer research[2][3][4].

HY-B1422S

9-Aminoacridine-13C6

9-Aminoacridine-13C6 is the ¹³C-labeled 9-Aminoacridine(HY-B1422). 9-Aminoacridine, a fluorescent probe, acts as an indicator of pH for quantitative determination of transmembrane pH gradients (inside acidic). 9-Aminoacridine is an antimicrobial. 9-Aminoacridine exerts its antimicrobial activity by interacting with specific bacterial DNA and disrupting the proton motive force in K. pneumoniae. 9-Aminoacridine is a HIV-1 inhibitor and inhibits HIV LTR transcription highly dependent on the presence and location of the amino moiety. 9-Aminoacridine inhibits virus replication in HIV-1 infected cell lines. 9-Aminoacridine is used as a Rifampin (RIF; HY-B0272) adjuvant for the multidrug-resistant K. pneumoniae infections .

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